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Information

The pharmacokinetics of Buy Viagra With Btc in the recommended dose range is linear.

Suction. After intake of Sildenafil Btc Pharmacy Online is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro How To Buy Viagra With Btc Online Pharmacy at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of How To Buy Viagra With Btc Online Pharmacy 100 mg average Cmax free Pay For Kamagra With Btc in plasma men is about 18 ng/ml (38 nm). Cmax when taking Sale Super Viagra Accept Btc inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Sale Super Viagra Accept Btc is 105 l. the Association of Sale Super Viagra Accept Btc and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Sale Super Viagra Accept Btc (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Pay For Female Viagra With Btc is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Sale Super Viagra Accept Btc, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Buy Sildenafil With Btc, and its activity against PDE-5 in vitro is about 50% of the activity of Buy Kamagra With Btc. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Sale Super Viagra Accept Btc. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Sale Super Viagra Accept Btc is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Generic Female Viagra For Btc is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Purchase Viagra For Btc Online Pharmacy was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Discount Red Viagra With Btc were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Buy Female Viagra With Btc, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Sale Super Viagra Accept Btc 25 mg), 74% (dose Buy Viagra With Btc 50 mg) and 82% (dose Sale Super Viagra Accept Btc 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Sale Super Viagra Accept Btc also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Sale Super Viagra Accept Btc.

Pharmacokinetics

Hearing impairment

Some post-marketing and clinical studies have reported cases of sudden hearing loss or impairment associated with the use of all PDE-5 inhibitors, including Kamagra For Btc. Most of these patients had risk factors for sudden impairment or hearing loss. There is no causal relationship between the use of PDE-5 inhibitors and sudden hearing impairment or hearing loss. In case of sudden hearing impairment or hearing loss while taking Sale Super Viagra Accept Btc, consult a doctor immediately.

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Sale Super Viagra Accept Btc enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Sildenafil Btc Pharmacy Online in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Sale Super Viagra Accept Btc in these patients should be used with caution (see With caution).

The incidence of nosebleeds in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (Kamagra Btc Pharmacy Online — 12.9%, placebo — 0%) than in patients with primary pulmonary arterial hypertension (Pay For Female Viagra With Btc — 3%, placebo — 2.4%). Patients receiving Sale Super Viagra Accept Btc in combination with an antagonist of vitamin K, the frequency of nasal bleeding was higher (8.8 percent) than patients who were not taking an antagonist of vitamin K (1.7 percent).

Use in conjunction with other means for the treatment of erectile dysfunction

The safety and efficacy of Pay For Female Viagra With Btc together with other PDE-5 inhibitors or other drugs for the treatment of pulmonary hypertension containing Sale Super Viagra Accept Btc (eg, Revatsio®), or other means for the treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see "Contraindications").

Influence on the ability to drive and mechanisms. In patients receiving Buy Sildenafil With Btc any negative effect on the ability to drive a car or other means was not observed. However, since when taking Buy Kamagra Btc may develop dizziness, lowering blood PRESSURE, the development of chromatopsia, blurred vision, etc. side effects, care should be taken when driving and doing other potentially dangerous activities that require increased concentration and speed of psychomotor reactions. Also, you should be careful about the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dosage regimen.

Dosage and administration

Inside, can be taken with or without water. When taking the drug, you should put a tablet, dispersed in the oral cavity, on the tongue, after which it will quickly dissolve, and it can be swallowed. The tablet should be taken immediately after opening the blister. Patients who are recommended a dose of Buy Sildenafil With Btc 100 mg, the second tablet of Purchase Viagra For Btc Online Pharmacy 50 mg should be taken after complete dissolution of the first tablet.

The recommended dose for most adult patients is 50 mg approximately 1 hour before sexual activity. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg (only tablets coated with a film, the appropriate dosage). The maximum recommended dose is 100 mg. Patients who are recommended a dose of Sale Super Viagra Accept Btc 100 mg, it is necessary to take 2 table., dispersible in the oral cavity, dosage 50 mg consecutively one after another. The maximum recommended frequency of use — 1 time per day. It should be borne in mind that the absorption of Sale Super Viagra Accept Btc significantly slows down when used in combination with fatty foods.

Special patient groups

Renal impairment. In mild to moderate renal failure dose adjustment is not required, in severe renal failure (Creatinine CL <30 ml/min) Sildenafil Btc Pharmacy Online dose should be reduced to 25 mg.

Hepatic impairment. Since the excretion of Pay For Viagra With Btc is disturbed in patients with liver damage (in particular, cirrhosis), the dose of Pay For Sildenafil With Btc should be reduced to 25 mg.

Joint application with other drugs. Joint use with ritonavir is not recommended. In any case, the maximum dose of Sale Super Viagra Accept Btc under any circumstances should not exceed 25 mg, and the frequency of application — 1 time in 48 h (see "Interaction").

When combined with inhibitors of CYP3A4 isoenzyme (erythromycin, saquinavir, ketoconazole, Itraconazole), the initial dose of Buy Sildenafil With Btc should be 25 mg (see "Interaction").

To minimize the risk of postural hypotension in patients taking α-blockers, Buy Kamagra Btc should be started only after achieving hemodynamic stabilization in these patients. Consideration should also be given to reducing the initial dose of Sale Super Viagra Accept Btc (see special instructions and Interactions).

Old age. Adjustment of the dose of Sale Super Viagra Accept Btc is not required.



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