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Viagra (sildenafil citrate)

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Information

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Some post-marketing and clinical studies have reported cases of sudden hearing loss or impairment associated with the use of all PDE-5 inhibitors, including Viagra For Erectile Dysfunction. Most of these patients had risk factors for sudden impairment or hearing loss. There is no causal relationship between the use of PDE-5 inhibitors and sudden hearing impairment or hearing loss. In case of sudden hearing impairment or hearing loss while taking Is Viagra A Cure For Erectile Dysfunction, consult a doctor immediately.

Bleedings

Is Viagra Only For Erectile Dysfunction enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Will Viagra Work For Erectile Dysfunction in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Treatment For Erectile Dysfunction Before Viagra in these patients should be used with caution (see With caution).

The incidence of nosebleeds in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (Does Viagra Work For Erectile Dysfunction — 12.9%, placebo — 0%) than in patients with primary pulmonary arterial hypertension (Viagra Cure Erectile Dysfunction — 3%, placebo — 2.4%). Patients receiving Treatment For Erectile Dysfunction Before Viagra in combination with an antagonist of vitamin K, the frequency of nasal bleeding was higher (8.8 percent) than patients who were not taking an antagonist of vitamin K (1.7 percent).

Use in conjunction with other means for the treatment of erectile dysfunction

The safety and efficacy of How Effective Is Viagra For Erectile Dysfunction together with other PDE-5 inhibitors or other drugs for the treatment of pulmonary hypertension containing Uses For Viagra Other Than Erectile Dysfunction (eg, Revatsio®), or other means for the treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see "Contraindications").

Influence on the ability to drive and mechanisms. In patients receiving Treatment For Erectile Dysfunction Before Viagra any negative effect on the ability to drive a car or other means was not observed. However, since when taking Can Viagra Be Used For Erectile Dysfunction may develop dizziness, lowering blood PRESSURE, the development of chromatopsia, blurred vision, etc. side effects, care should be taken when driving and doing other potentially dangerous activities that require increased concentration and speed of psychomotor reactions. Also, you should be careful about the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dosage regimen.

The pharmacokinetics of Herbal Viagra For Erectile Dysfunction in the recommended dose range is linear.

Suction. After intake of Treatment For Erectile Dysfunction Before Viagra is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Treatment For Erectile Dysfunction Before Viagra at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Is Viagra Only Used For Erectile Dysfunction 100 mg average Cmax free Treatment For Erectile Dysfunction Before Viagra in plasma men is about 18 ng/ml (38 nm). Cmax when taking Generic Viagra For Erectile Dysfunction inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Treatment For Erectile Dysfunction Before Viagra is 105 l. the Association of Viagra Without Erectile Dysfunction and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Treatment For Erectile Dysfunction Before Viagra (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Treatment For Erectile Dysfunction Before Viagra is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Treatment For Erectile Dysfunction Before Viagra, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Treatment For Erectile Dysfunction Before Viagra, and its activity against PDE-5 in vitro is about 50% of the activity of Generic Viagra For Erectile Dysfunction. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Treatment For Erectile Dysfunction Before Viagra. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Treatment For Erectile Dysfunction Before Viagra is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Viagra Works Erectile Dysfunction is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Clinical data

Cardiac studies. The use of Can Viagra Be Used For Erectile Dysfunction in doses up to 100 mg did not lead to clinically significant ECG changes in healthy volunteers. The maximum decrease in systolic pressure in the supine position after taking Treatment For Erectile Dysfunction Before Viagra at a dose of 100 mg was 8.3 mm Hg.art., and diastolic pressure — 5.3 mm Hg.a More pronounced, but also transient effect on blood PRESSURE was observed in patients taking nitrates (see "Contraindications" and "Interaction").

In a study of the hemodynamic effect of Treatment For Erectile Dysfunction Before Viagra in a single dose of 100 mg in 14 patients with severe coronary artery disease (more than 70% of patients had stenosis of at least one coronary artery), systolic and diastolic resting pressure decreased by 7 and 6%, respectively, and pulmonary systolic pressure decreased by 9%. Treatment For Erectile Dysfunction Before Viagra did not affect cardiac output and did not interfere with blood flow in stenotic coronary arteries, and also led to an increase (by about 13%) of adenosine-induced coronary flow in both stenotic and intact coronary arteries. In a double-blind placebo-controlled study of 144 patients with erectile dysfunction and stable angina, taking antianginal drugs (except nitrates), exercise was performed until the severity of symptoms of angina increased. The duration of the exercise was significantly longer (19.9 seconds; 0.9–38.9 seconds) in patients taking Viagra Dose For Erectile Dysfunction in a single dose of 100 mg, compared with patients receiving placebo.

In a randomized double-blind placebo-controlled study, the effect of changing the dose of Viagra Human Erectile Dysfunction (up to 100 mg) in men (n=568) with erectile dysfunction and hypertension, taking more than two antihypertensive drugs, was studied. Treatment For Erectile Dysfunction Before Viagra improved erection in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable to that in other groups of patients, as well as in those taking more than three antihypertensive drugs.

Studies of visual impairment. In some patients, 1 h after taking Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis at a dose of 100 mg with the Farnsworth-Mansell test 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green). After 2 hours after taking the drug, these changes were absent. It is believed that color vision impairment is caused by inhibition of PDE-6, which is involved in the process of color transmission in the retina. Treatment For Erectile Dysfunction Before Viagra had no effect on visual acuity, contrast perception, electroretinogram, IOP or pupil diameter.

Influence of Viagra For Diabetes Erectile Dysfunction on other drugs

Is Viagra Only Used For Erectile Dysfunction is a weak inhibitor of cytochrome P450 — 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 ISOENZYMES (IC50 >150 µmol). When taking Does Medicare Cover Viagra For Erectile Dysfunction in recommended doses, its Cmax is about 1 µmol, so it is unlikely that Viagra For Non Erectile Dysfunction can affect the clearance of the substrates of these isoenzymes.

Treatment For Erectile Dysfunction Before Viagra increases the hypotensive effect of nitrates both with long-term use of the latter, and with their appointment for urgent indications. In this regard, the use of Can Viagra Be Used For Erectile Dysfunction in combination with nitrates or nitric oxide donators is contraindicated. While taking α-adrenoblocker doxazosin (4 and 8 mg) and Treatment For Erectile Dysfunction Before Viagra (25, 50 and 100 mg) in patients with benign prostate hyperplasia with stable hemodynamics, the average additional decrease in sad/dad in the supine position was 7/7, 9/5 and 8/4 mm Hg.article, respectively, while in the standing position — 6/6, 11/4 mmHg, and 4/5.art. respectively. Reported rare cases of symptomatic postural hypotension in such patients, manifested in the form of dizziness (without fainting). In some sensitive patients receiving α-blockers, simultaneous use of Treatment For Erectile Dysfunction Before Viagra can lead to symptomatic hypotension.

There were no signs of significant interaction with tolbutamide (250 mg) or warfarin (40 mg), which are metabolized by CYP2C9 isoenzyme.

Treatment For Erectile Dysfunction Before Viagra (100 mg) has no effect on the pharmacokinetics of the HIV protease inhibitor, saquinavir, which is a substrate of CYP3A4 isoenzyme, at its constant level in the blood.

The simultaneous use of Treatment For Erectile Dysfunction Before Viagra at equilibrium (80 mg 3 times a day) leads to an increase in the AUC and Cmax of bosentan (125 mg 2 times a day) by 49.8 and 42%, respectively.

Treatment For Erectile Dysfunction Before Viagra (50 mg) does not cause an additional increase in bleeding time when taking acetylsalicylic acid (150 mg).

Treatment For Erectile Dysfunction Before Viagra (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with Cmax of alcohol in the blood on average 0.08‰ (80 mg/DL).

In patients with hypertension, no signs of interaction of Treatment For Erectile Dysfunction Before Viagra (100 mg) with amlodipine were found. The average additional reduction in blood PRESSURE in the supine position is 8 mm Hg.V. (systolic) and 7 mm Hg.V. (diastolic).

The use of Is Viagra Only Used For Erectile Dysfunction in combination with antihypertensive agents does not lead to additional side effects.



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