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Cardiac studies. The use of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis in doses up to 100 mg did not lead to clinically significant ECG changes in healthy volunteers. The maximum decrease in systolic pressure in the supine position after taking Herbal Viagra For Erectile Dysfunction at a dose of 100 mg was 8.3 mm Hg.art., and diastolic pressure — 5.3 mm Hg.a More pronounced, but also transient effect on blood PRESSURE was observed in patients taking nitrates (see "Contraindications" and "Interaction").

In a study of the hemodynamic effect of Sildenafil For Erectile Dysfunction Dosage in a single dose of 100 mg in 14 patients with severe coronary artery disease (more than 70% of patients had stenosis of at least one coronary artery), systolic and diastolic resting pressure decreased by 7 and 6%, respectively, and pulmonary systolic pressure decreased by 9%. Natural Viagra For Erectile Dysfunction did not affect cardiac output and did not interfere with blood flow in stenotic coronary arteries, and also led to an increase (by about 13%) of adenosine-induced coronary flow in both stenotic and intact coronary arteries. In a double-blind placebo-controlled study of 144 patients with erectile dysfunction and stable angina, taking antianginal drugs (except nitrates), exercise was performed until the severity of symptoms of angina increased. The duration of the exercise was significantly longer (19.9 seconds; 0.9–38.9 seconds) in patients taking Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis in a single dose of 100 mg, compared with patients receiving placebo.

In a randomized double-blind placebo-controlled study, the effect of changing the dose of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis (up to 100 mg) in men (n=568) with erectile dysfunction and hypertension, taking more than two antihypertensive drugs, was studied. Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis improved erection in 71% of men compared to 18% in the placebo group. The frequency of adverse effects was comparable to that in other groups of patients, as well as in those taking more than three antihypertensive drugs.

Studies of visual impairment. In some patients, 1 h after taking Viagra And Other Erectile Dysfunction Drugs at a dose of 100 mg with the Farnsworth-Mansell test 100 revealed a slight and transient violation of the ability to distinguish shades of color (blue/green). After 2 hours after taking the drug, these changes were absent. It is believed that color vision impairment is caused by inhibition of PDE-6, which is involved in the process of color transmission in the retina. Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis had no effect on visual acuity, contrast perception, electroretinogram, IOP or pupil diameter.

Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis 25 mg), 74% (dose Alternative To Viagra For Erectile Dysfunction 50 mg) and 82% (dose Uses For Viagra Other Than Erectile Dysfunction 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Natural Viagra For Erectile Dysfunction also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Viagra And Other Erectile Dysfunction Drugs.

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During the post-marketing use of Viagra Tablet For Erectile Dysfunction for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Viagra Cure Erectile Dysfunction. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

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Is Viagra Only For Erectile Dysfunction has a systemic vasodilating effect, leading to a transient decrease in blood PRESSURE, which is not clinically significant and does not lead to any consequences in most patients. However, before prescribing Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis, the doctor should carefully assess the risk of possible undesirable manifestations of vasodilating action in patients with relevant diseases, especially against the background of sexual activity. Increased susceptibility to vasodilators is observed in patients with obstruction of the output tract of the left ventricle (aortic stenosis, GOCMP), as well as with the rare syndrome of multiple systemic atrophy, manifested by a severe violation of the regulation of blood PRESSURE from the autonomic nervous system.

Since the combined use of Generic Viagra For Erectile Dysfunction and α-blockers can lead to symptomatic hypotension in some sensitive patients, Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis should be used with caution in patients taking α-blockers (see "Interaction"). To minimize the risk of postural hypotension in patients taking α-blockers, the drug Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis should be started only after achieving stabilization of hemodynamic parameters in these patients. It should also consider reducing the initial dose of Dose Of Viagra For Erectile Dysfunction (see. "Dosage and administration"). The doctor should inform patients about what actions should be taken in case of symptoms of postural hypotension.

The pharmacokinetics of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis in the recommended dose range is linear.

Suction. After intake of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Viagra Without Erectile Dysfunction at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Sildenafil For Erectile Dysfunction Dosage 100 mg average Cmax free Viagra And Other Erectile Dysfunction Drugs in plasma men is about 18 ng/ml (38 nm). Cmax when taking Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis is 105 l. the Association of Can Viagra Be Used For Erectile Dysfunction and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Will Viagra Work For Erectile Dysfunction, and its activity against PDE-5 in vitro is about 50% of the activity of Sildenafil For Erectile Dysfunction. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Viagra Cure Erectile Dysfunction is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).



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