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Viagra (sildenafil citrate)

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The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.


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Information

Dosage and administration

Inside, can be taken with or without water. When taking the drug, you should put a tablet, dispersed in the oral cavity, on the tongue, after which it will quickly dissolve, and it can be swallowed. The tablet should be taken immediately after opening the blister. Patients who are recommended a dose of Viagra And Other Erectile Dysfunction Drugs 100 mg, the second tablet of Viagra And Other Erectile Dysfunction Drugs 50 mg should be taken after complete dissolution of the first tablet.

The recommended dose for most adult patients is 50 mg approximately 1 hour before sexual activity. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg (only tablets coated with a film, the appropriate dosage). The maximum recommended dose is 100 mg. Patients who are recommended a dose of Viagra Erectile Dysfunction Treatment 100 mg, it is necessary to take 2 table., dispersible in the oral cavity, dosage 50 mg consecutively one after another. The maximum recommended frequency of use — 1 time per day. It should be borne in mind that the absorption of Viagra Erectile Dysfunction Treatment significantly slows down when used in combination with fatty foods.

Special patient groups

Renal impairment. In mild to moderate renal failure dose adjustment is not required, in severe renal failure (Creatinine CL <30 ml/min) Viagra And Other Erectile Dysfunction Drugs dose should be reduced to 25 mg.

Hepatic impairment. Since the excretion of Viagra And Other Erectile Dysfunction Drugs is disturbed in patients with liver damage (in particular, cirrhosis), the dose of How Effective Is Viagra For Erectile Dysfunction should be reduced to 25 mg.

Joint application with other drugs. Joint use with ritonavir is not recommended. In any case, the maximum dose of Does Medicare Cover Viagra For Erectile Dysfunction under any circumstances should not exceed 25 mg, and the frequency of application — 1 time in 48 h (see "Interaction").

When combined with inhibitors of CYP3A4 isoenzyme (erythromycin, saquinavir, ketoconazole, Itraconazole), the initial dose of Viagra And Other Erectile Dysfunction Drugs should be 25 mg (see "Interaction").

To minimize the risk of postural hypotension in patients taking α-blockers, Viagra And Other Erectile Dysfunction Drugs should be started only after achieving hemodynamic stabilization in these patients. Consideration should also be given to reducing the initial dose of Does Medicare Cover Viagra For Erectile Dysfunction (see special instructions and Interactions).

Old age. Adjustment of the dose of Viagra And Other Erectile Dysfunction Drugs is not required.

The pharmacokinetics of Viagra And Other Erectile Dysfunction Drugs in the recommended dose range is linear.

Suction. After intake of Alternative To Viagra For Erectile Dysfunction is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Alternative To Viagra For Erectile Dysfunction at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Viagra And Other Erectile Dysfunction Drugs 100 mg average Cmax free Generic Viagra For Erectile Dysfunction in plasma men is about 18 ng/ml (38 nm). Cmax when taking Viagra And Other Erectile Dysfunction Drugs inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Viagra And Other Erectile Dysfunction Drugs is 105 l. the Association of Which Is Better For Erectile Dysfunction Viagra Or Cialis and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Viagra And Other Erectile Dysfunction Drugs (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Viagra And Other Erectile Dysfunction Drugs is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Alternative To Viagra For Erectile Dysfunction, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Viagra And Other Erectile Dysfunction Drugs, and its activity against PDE-5 in vitro is about 50% of the activity of Viagra For Psychological Erectile Dysfunction. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Viagra And Other Erectile Dysfunction Drugs. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Which Is Better For Erectile Dysfunction Viagra Or Cialis is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Viagra Without Erectile Dysfunction is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Hearing impairment

Some post-marketing and clinical studies have reported cases of sudden hearing loss or impairment associated with the use of all PDE-5 inhibitors, including Viagra And Other Erectile Dysfunction Drugs. Most of these patients had risk factors for sudden impairment or hearing loss. There is no causal relationship between the use of PDE-5 inhibitors and sudden hearing impairment or hearing loss. In case of sudden hearing impairment or hearing loss while taking Does Viagra Work For Erectile Dysfunction, consult a doctor immediately.

Bleedings

Is Viagra Good For Erectile Dysfunction enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Viagra Erectile Dysfunction Dose in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Viagra For Psychological Erectile Dysfunction in these patients should be used with caution (see With caution).

The incidence of nosebleeds in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (Viagra And Other Erectile Dysfunction Drugs — 12.9%, placebo — 0%) than in patients with primary pulmonary arterial hypertension (Viagra And Other Erectile Dysfunction Drugs — 3%, placebo — 2.4%). Patients receiving Can Viagra Be Used For Erectile Dysfunction in combination with an antagonist of vitamin K, the frequency of nasal bleeding was higher (8.8 percent) than patients who were not taking an antagonist of vitamin K (1.7 percent).

Use in conjunction with other means for the treatment of erectile dysfunction

The safety and efficacy of Viagra And Other Erectile Dysfunction Drugs together with other PDE-5 inhibitors or other drugs for the treatment of pulmonary hypertension containing Viagra And Other Erectile Dysfunction Drugs (eg, Revatsio®), or other means for the treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see "Contraindications").

Influence on the ability to drive and mechanisms. In patients receiving Viagra And Other Erectile Dysfunction Drugs any negative effect on the ability to drive a car or other means was not observed. However, since when taking Viagra And Other Erectile Dysfunction Drugs may develop dizziness, lowering blood PRESSURE, the development of chromatopsia, blurred vision, etc. side effects, care should be taken when driving and doing other potentially dangerous activities that require increased concentration and speed of psychomotor reactions. Also, you should be careful about the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dosage regimen.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Viagra And Other Erectile Dysfunction Drugs, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Viagra And Other Erectile Dysfunction Drugs therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Sildenafil Used For Erectile Dysfunction, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Viagra And Other Erectile Dysfunction Drugs is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Uses For Viagra Other Than Erectile Dysfunction in patients with retinitis pigmentosa absent, so these patients should not be used Viagra And Other Erectile Dysfunction Drugs (see "Contraindications").



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