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Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Which Is Better For Erectile Dysfunction Viagra Or Cialis was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Which Is Better For Erectile Dysfunction Viagra Or Cialis were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Viagra Erectile Dysfunction Treatment, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Which Is Better For Erectile Dysfunction Viagra Or Cialis 25 mg), 74% (dose Generic Viagra For Erectile Dysfunction 50 mg) and 82% (dose Which Is Better For Erectile Dysfunction Viagra Or Cialis 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Which Is Better For Erectile Dysfunction Viagra Or Cialis also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Sildenafil For Erectile Dysfunction.

Pharmacokinetics

Contraindications

hypersensitivity to Herbal Viagra For Erectile Dysfunction or any other component of the drug;

application in patients receiving constantly or intermittently nitric oxide donators, organic nitrates or nitrites in any form, as Which Is Better For Erectile Dysfunction Viagra Or Cialis enhances the hypotensive effect of nitrates (see "Interaction»);

the combined use of inhibitors of PDE5, including Viagra Erectile Dysfunction Dose, called guanylate cyclase stimulants such as riociguat, because it can lead to symptomatic hypotension;

concomitant use with other agents for the treatment of erectile dysfunction (safety and efficacy of Viagra Erectile Dysfunction Dose when used together has not been studied (see. "Special instructions»);

lactose intolerance, lactase deficiency, glucose-papacosma malabsorption;

severe liver failure (class C classification for child-Pugh);

simultaneous administration of ritonavir;

severe cardiovascular diseases (severe heart failure, unstable angina, stroke or myocardial infarction during the last 6 months, life-threatening arrhythmias, hypertension (BP >170/100 mm Hg). art.) or hypotension (blood PRESSURE <90/50 mm Hg.art.) (see "Special instructions»);

patients with episodes of development partizanai anterior ischemic optic neuropathies (NESN) with loss of vision in one eye;

hereditary retinitis pigmentosa (see special instructions»);

according to the registered indication is not intended for use in women;

according to the registered indication is not intended for use in children under 18 years.

With caution: anatomic deformity of the penis (angulation, cavernous fibrosis or Peyronie's disease) (see "Special instructions"); diseases of, predisposing to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, thrombocythemia) (see "Special instructions"); diseases accompanied by haemorrhage; ulcer disease of stomach and duodenum in the acute phase; liver dysfunction; severe renal insufficiency (Cl creatinine <30 ml/min); patients with an episode of partizanai development of the anterior ischemic optic neuropathies in history (see "Special instructions); simultaneous reception of blockers α-adrenergic receptors.

Use during pregnancy and breast-feeding

According to the registered indication, the drug is not intended for use in women.

Influence of Which Is Better For Erectile Dysfunction Viagra Or Cialis on other drugs

Which Is Better For Erectile Dysfunction Viagra Or Cialis is a weak inhibitor of cytochrome P450 — 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 ISOENZYMES (IC50 >150 µmol). When taking Which Is Better For Erectile Dysfunction Viagra Or Cialis in recommended doses, its Cmax is about 1 µmol, so it is unlikely that Herbal Viagra For Erectile Dysfunction can affect the clearance of the substrates of these isoenzymes.

Which Is Better For Erectile Dysfunction Viagra Or Cialis increases the hypotensive effect of nitrates both with long-term use of the latter, and with their appointment for urgent indications. In this regard, the use of Which Is Better For Erectile Dysfunction Viagra Or Cialis in combination with nitrates or nitric oxide donators is contraindicated. While taking α-adrenoblocker doxazosin (4 and 8 mg) and Is Viagra Only Used For Erectile Dysfunction (25, 50 and 100 mg) in patients with benign prostate hyperplasia with stable hemodynamics, the average additional decrease in sad/dad in the supine position was 7/7, 9/5 and 8/4 mm Hg.article, respectively, while in the standing position — 6/6, 11/4 mmHg, and 4/5.art. respectively. Reported rare cases of symptomatic postural hypotension in such patients, manifested in the form of dizziness (without fainting). In some sensitive patients receiving α-blockers, simultaneous use of Sildenafil For Erectile Dysfunction Dosage can lead to symptomatic hypotension.

There were no signs of significant interaction with tolbutamide (250 mg) or warfarin (40 mg), which are metabolized by CYP2C9 isoenzyme.

Which Is Better For Erectile Dysfunction Viagra Or Cialis (100 mg) has no effect on the pharmacokinetics of the HIV protease inhibitor, saquinavir, which is a substrate of CYP3A4 isoenzyme, at its constant level in the blood.

The simultaneous use of Which Is Better For Erectile Dysfunction Viagra Or Cialis at equilibrium (80 mg 3 times a day) leads to an increase in the AUC and Cmax of bosentan (125 mg 2 times a day) by 49.8 and 42%, respectively.

Will Viagra Work For Erectile Dysfunction (50 mg) does not cause an additional increase in bleeding time when taking acetylsalicylic acid (150 mg).

Which Is Better For Erectile Dysfunction Viagra Or Cialis (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with Cmax of alcohol in the blood on average 0.08‰ (80 mg/DL).

In patients with hypertension, no signs of interaction of Generic Viagra For Erectile Dysfunction (100 mg) with amlodipine were found. The average additional reduction in blood PRESSURE in the supine position is 8 mm Hg.V. (systolic) and 7 mm Hg.V. (diastolic).

The use of Which Is Better For Erectile Dysfunction Viagra Or Cialis in combination with antihypertensive agents does not lead to additional side effects.

The pharmacokinetics of Which Is Better For Erectile Dysfunction Viagra Or Cialis in the recommended dose range is linear.

Suction. After intake of Which Is Better For Erectile Dysfunction Viagra Or Cialis is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Sildenafil Used For Erectile Dysfunction at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Viagra Dose For Erectile Dysfunction 100 mg average Cmax free Which Is Better For Erectile Dysfunction Viagra Or Cialis in plasma men is about 18 ng/ml (38 nm). Cmax when taking Will Viagra Work For Erectile Dysfunction inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Which Is Better For Erectile Dysfunction Viagra Or Cialis is 105 l. the Association of Natural Viagra For Erectile Dysfunction and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Sildenafil For Erectile Dysfunction Dosage (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Viagra Tablet For Erectile Dysfunction is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Which Is Better For Erectile Dysfunction Viagra Or Cialis, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Which Is Better For Erectile Dysfunction Viagra Or Cialis, and its activity against PDE-5 in vitro is about 50% of the activity of Viagra Human Erectile Dysfunction. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Which Drug For Erectile Dysfunction Is Better Viagra Or Cialis. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Which Is Better For Erectile Dysfunction Viagra Or Cialis is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Which Is Better For Erectile Dysfunction Viagra Or Cialis is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).



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